Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation
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چکیده
منابع مشابه
Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation
BACKGROUND Trichinella spiralis expresses paramyosin (Ts-Pmy) as a defense mechanism. Ts-Pmy is a functional protein with binding activity to human complement C8 and C9 and thus plays a role in evading the attack of the host's immune system. In the present study, the binding activity of Ts-Pmy to human complement C1q and its ability to inhibit classical complement activation were investigated. ...
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As a multicellular parasitic nematode, Trichinella spiralis regulates host immune responses by producing a variety of immunomodulatory molecules to escape from host immune attack, but the mechanisms underlying the immune evasion are not well understood. Here, we identified that T. spiralis calreticulin (Ts-CRT), a Ca2+-binding protein, facilitated T. spiralis immune evasion by interacting with ...
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BACKGROUND Paramyosin is a thick myofibrillar protein found exclusively in invertebrates. Evidence suggested that paramyosin from helminths serves not only as a structural protein but also as an immunomodulatory agent. We previously reported that recombinant Trichinella spiralis paramyosin (Ts-Pmy) elicited a partial protective immunity in mice. In this study, the ability of Ts-Pmy to bind host...
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ژورنال
عنوان ژورنال: PLOS Neglected Tropical Diseases
سال: 2015
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0004310